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In a recently published paper in the Journal of Drug Assessment, Axthelm et al.1 reported on the effectiveness of single-pill combination (SPC) aliskiren 300 mg/amlodipine 10 mg in high-risk subgroups of hypertensive patients with uncontrolled blood pressure (BP). Briefly, 4-week’s treatment with SPC aliskiren 300 mg/amlodipine 10 mg resulted in further lowering of both systolic and diastolic BP in elderly (≥65 years), overweight/obese (body mass index ≥25 kg/m2) and diabetic patients as well as individuals with at least one metabolic risk factor (i.e., serum glucose ≥5.56 mmol/l, low density lipoprotein cholesterol ≥4.16 mmol/l or triglycerides ≥2.28 mmol/l) that were inadequately controlled by prior use of SPC olmesartan 40 mg/amlodipine 10 mg1. The efficacy and safety of aliskiren/amlodipine SPCs in patients previously on either drug monotherapy were also reported in earlier studies. Of note, adverse effects such as peripheral edema as well as discontinuation rates were fewer in the SPC groups2–4.. Quantitative analyses of fluorescence signals (figure 1b no prescription isotretinoin 3b and 5b) and dark-brown staining (figure 2b, 4b and 6b) revealed that the highest levels of expression of NHE-1, 2 and 4 protein were observed in the luminal epithelia of the endocervix of 100 mg/kg/day genistein treated rats, followed by 50mg/kg/day genistein-treated rats. Low levels of expression was observed in rats receiving 25 mg/kg/day genistein treatment.. not be falsely reassured by negative screening results.. The information sheet produced by AMS.
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Who wouldn’t want a metaphorical stunt double to take the perilous fall that comes with the pain of loss or profound disappointment? The poems in When the Heart Needs a Stunt Double by Diane DeCillis consider resourceful ways in which we become our own stunt double as we explore through a poet’s eyes the anatomy of the mind, body, and soul.


This is that rare book that is both funny and momentous. Her lyrical evocations of people and places are full of empathy, tenderness, and whimsical irony. DeCillis captures our humanity in all its moods—no small task.


When the Heart Needs a Stunt Double takes us on a journey of what it means to be fully human. It highlights the gifts we find in humor, nature, art, food, and how we celebrate the beauty of our scars. These are love poems: to others, to the self, to the body. DeCillis makes it clear that wounds need attention and care, but that loss always strengthens us.


Wayne State University Press 2021

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